CLINICAL TRIAL SUMMARY

MDACC Study No:2011-0530 (clinicaltrials.gov NCT No: NCT01438554)
Title:A Phase I Study Determining the Safety and Tolerability of Combination Therapy with Pazopanib, a VEGFR/PDGFR/Raf Inhibitor, and GSK1120212, a MEK Inhibitor, in Advanced Solid Tumors Enriched with Patients with Advanced Differentiated Thyroid Cancer, Soft Tissue Sarcoma, and Cholangiocarcinoma.
Principal Investigator:Ralph Zinner
Treatment Agent:GSK1120212 ; Pazopanib
Study Status:Open
Study Description:The goal of this clinical research study is to find the highest tolerable dose
levels of pazopanib and GSK1120212 that can be given in combination to
patients with advanced cancer.

Pazopanib and GSK1120212 are designed to block certain proteins that cause
cancer cells to grow and multiply. This may cause the cancer cells to die.

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Disease Group:Advanced Cancers; Gastrointestinal; Sarcoma; Solid Tumors; Thyroid
Phase of Study:Phase I
Treatment Agents:GSK1120212
Pazopanib
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:National Comprehensive Cancer Network (NCCN)
Return Visit:
Home Care:


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Physician Name:Ralph Zinner
Dept:Investigational Cancer Therapeutics
For Clinical Trial Enrollment:713-794-1226
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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