CLINICAL TRIAL SUMMARY

MDACC Study No:2012-0734 (clinicaltrials.gov NCT No: NCT01807598)
Title:A study of brentuximab vedotin (SGN-35) in CD30-positive systemic mastocytosis +/- an associated hematological clonal
non-mast cell lineage disease (AHNMD)
Principal Investigator:Srdan Verstovsek
Treatment Agent:SGN-35
Study Status:Open
Study Description:The goal of this clinical research study is to learn if the study drug Adcetris
(brentuximab vedotin) can help to control SM. The safety of this drug will
also be studied.

Brentuximab vedotin is designed to find a certain protein (CD30) on cancer
cells and bind to it. This may kill the cancer cells.

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Disease Group:Myeloproliferative Diseases
Phase of Study:Phase II
Treatment Agents:SGN-35
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Seattle Genetics
Stanford University
Return Visit:
Home Care:


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Physician Name:Srdan Verstovsek
Dept:Leukemia
For Clinical Trial Enrollment:713-792-7305
For General Questions about Clinical Trials:1-877-MDA-6789


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