MDACC Study No:2012-1047 ( NCT No: NCT01892371)
Title:Phase I/II Study of the Combination of Quizartinib (AC220) with 5-Azacytidine or Low-Dose Cytarabine for the Treatment of Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
Principal Investigator:Jorge Cortes
Treatment Agent:5-Azacytidine; AC220; Cytarabine
Study Status:Open
Study Description:The goal of the Phase 1 part of this clinical research study is to find the
highest tolerable dose of AC220 (quizartinib) that can be given with either
5-azacitidine (azacitidine) or cytarabine to patients with AML or MDS.

The goal of the Phase 2 part of the study is to learn if quizartinib with
either azacitidine or cytarabine can help to control AML or MDS. The safety of
these combinations will also be studied.
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Disease Group:Leukemia
Phase of Study:Phase I/Phase II
Treatment Agents:5-Azacytidine
Treatment Location:Only at MDACC
Estimated Length of Stay in Houston:
Supported By:Ambit Biosciences
Leukemia SPORE
Return Visit:
Home Care:

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Physician Name:Jorge Cortes
For Clinical Trial Enrollment:713-794-5783
For General Questions about Clinical Trials:1-877-MDA-6789

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