CLINICAL TRIAL SUMMARY

MDACC Study No:2013-0001 (clinicaltrials.gov NCT No: NCT01907815)
Title:A Phase II Study of MEK 1/2 Inhibitor Trametinib in Combination with AKT Inhibitor GSK2141795 in Acute Myeloid Leukemia (AML) with RAS Mutations
Principal Investigator:Nitin Jain
Treatment Agent:GSK2141795; Trametinib
Study Status:Open
Study Description:The goal of this clinical research study is to learn if a combination of
trametinib and GSK2141795 can help to control AML. The highest tolerable dose
level as well as the safety of the drugs will also be studied.

Trametinib is designed to block MEK proteins, and GSK2141795 is designed to
block AKT proteins. These proteins cause cancer cells to grow and multiply.
Blocking these proteins may possibly cause the cancer cells to die.

The combination of trametinib and GSK2141795 being used to treat AML with RAS
mutations is considered experimental.

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Disease Group:Leukemia
Phase of Study:Phase II
Treatment Agents:GSK2141795
Trametinib
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:National Cancer Institute
Return Visit:
Home Care:


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Physician Name:Nitin Jain
Dept:Leukemia
For Clinical Trial Enrollment:713-794-1628
For General Questions about Clinical Trials:1-877-MDA-6789


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