| Exclusion Criteria: | 1) Patients must not be on chronic daily treatment with aspirin greater than 325 mg/day or non-steroidal inflammatory medications.
2) Patients with the following uncontrolled intercurrent medical conditions are excluded: 1. Active infection 2. Uncontrolled high blood pressure (defined as > 140/90 mmHg) 3. Symptomatic congestive heart failure (defined as NYHA >/= to II) 4. Unstable angina 5. Cardiac arrhythmia 6. Myocardial infarction < 6 months prior to registration 7. Psychiatric illness/social situation that would limit compliance with study requirements 8. Serious, non-healing wound, ulcer, or bone fracture 9. Evidence of bleeding diathesis or coagulopathy. 10. Clinically significant peripheral vascular disease.
3) Patients with the following history of evidence of central nervous system disease are excluded: 1. Brain metastases 2. Primary brain tumor 3. Seizures not controlled with standard medical therapy 4. Embolic or hemorrhagic stroke or prior transient ischemic attack.
4) Patients who have undergone the following invasive procedures are excluded: 1. Major surgical procedure, open biopsy, or significant traumatic injury with 6 weeks prior to day 1 of treatment. 2. Fine needle aspiration or core needle biopsy or other minor surgical procedure within 7 days prior to day 1 of treatment. 3. Anticipation of the need for a major surgical procedure during the course of the study.
5) Women who are pregnant or lactating are not eligible for this study.
6) History of abdominal fistula, GI perforation, or intra-abdominal abscess within 6 months of Day 0 is an exclusion criteria.
7) Patients with prior tumor-related hemorrhage (any grade) are not eligible.
8) Patients on warfarin or any other anticoagulant (any dose) are not eligible. |