MDACC Study Summary 2006-0102 (Archived)

Study Summary
No. 2006-0102:.......Brain......Jeffrey Weinberg......Neurosurgery

Study Summary Title



Study Summary Number:	2006-0102

Study Title:	Intraoperative Optical Imaging of Brain Function

Physician

New Patient Referral



Name:	Jeffrey Weinberg	Patients Call:	800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)

Dept:	Neurosurgery	Referring MD Call:	800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)

Phone:	713-792-2400 Contact us about clinical trials

General Information



Disease Group:	Brain	Supported By:	N/A

Phase of Study:	N/A	Return Visit:	None

Treatment Agents:	None	Home Care:	None

Treatment Loc:	Only at MDACC

Estimated Length of Stay in Houston:	Patients will be hospitalized for 3 to 4 days for the craniotomy which is standard and not affected by enrollment on the protocol.


Description/ Intervention:	The goal of this clinical research study is to test a new kind of scan called speckle-contrast imaging that may help researchers more easily find areas of the brain during surgery that control functions such as finger movement and feeling.

Study Objectives / Outcomes

The goal of this proposal is to test the performance of a novel optical imaging system for real-time quantitative imaging of brain function through multiple hemodynamic measures during neurosurgery.

This pilot study encompasses two sub-aims:

Aim 1. Evaluate the ability of laser speckle contrast imaging to image cerebral blood flow (CBF) intraoperatively. We will image the changes in CBF in response to somatosensory stimulation. (5 patients).

Aim 2.Simultaneously image hemoglobin oxygenation, blood volume, blood flow, and cerebral metabolic rate of oxygen (CMRO₂) changes during somatosensory stimulation using a combined laser speckle and multi-wavelength reflectance imaging system. (5 patients).

Study Status Information



Study Activation / Registration Date:	02/11/2008

IRB Review and Approval Date:	06/09/2006

Study Type:	Other

Recruitment Status:	Terminated

Projected Accrual:	N/A

Enrollment Eligibility

If you do not meet the enrollment eligibility, there may be other treatment options for you. Please Contact the Referral Office for more information.

Inclusion Criteria:

1) Location of planned resection near somatosensory cortex.

2) Planned intraoperative electrocortical mapping.

3) Able to render written informed consent.

Exclusion Criteria:

1) Patients with a hemiparesis graded 3/5 (active movement against gravity) or worse that is attributable to the lesion undergoing resection. Unpublished data from MDACC Department of Neurosurgery suggests that cortical mapping is ineffective in these patients because an adequate cortical response is not detected

2) Patients with a vascular malformation within the proximity of the cortex area imaged.

Links

Registration Number: NCT00632437
Study Information on Clinical Trials Registry (clinicaltrials.gov)