MDACC Study Summary 2006-0333

Study Summary
No. 2006-0333:.......Genitourinary......Haesun Choi......Diagnostic Radiology

Study Summary Title



Study Summary Number:	2006-0333

Study Title:	Feasibility study of 3T endorectal magnetic resonance spectroscopic imaging (MRSI) of prostate

Physician

New Patient Referral



Name:	Haesun Choi	Patients Call:	800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)

Dept:	Diagnostic Radiology	Referring MD Call:	800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)

Phone:	713-745-4693 Contact us about clinical trials

General Information



Disease Group:	Genitourinary	Supported By:	N/A

Phase of Study:	N/A	Return Visit:	NA

Treatment Agents:	None	Home Care:	NA

Treatment Loc:	Only at MDACC

Estimated Length of Stay in Houston:	NA

Description/
Intervention:

The goal of this clinical research study is to compare the technical quality of
2 ways of performing endorectal magnetic resonance spectroscopy imaging (MRSI)
of the prostate using a "3 Tesla (3T)" scanner. Researchers will compare the
use of perfluorocarbon compound (PFC) within the endorectal coil with the use
of air in order to try to find out which technique may help to produce
better-quality images.

Study Objectives / Outcomes

The objective of this study is to evaluate the feasibility of 3T magnetic resonance spectroscopic imaging (MRSI) of the prostate in improving the spectral resolution, using a PFC-filled endorectal coil,

Specific Aim 1: To compare the spectral quality, measured in Hz (linewidth), of 3T MRSI performed with an air-filled endorectal coil (AIR-MRSI) and a PFC-filled endorectal coil (PFC-MRSI).

Specific Aim 2: To compare the quality of spectra of PFC-MRSI by grading the overall quality of MRSI data of each patient subjectively as being "excellent," "good," "fair," "poor," and "non-diagnostic," based on the status of subjective spectral resolution of Cho, Cr and Po peaks, signal to noise ratio (SNR), baseline distortion, and fat contamination.

Study Status Information



Study Activation / Registration Date:	01/18/2007

IRB Review and Approval Date:	06/07/2006

Study Type:	Other

Recruitment Status:	Open

Projected Accrual:	N/A

Enrollment Eligibility

If you do not meet the enrollment eligibility, there may be other treatment options for you. Please Contact the Referral Office for more information.

Inclusion Criteria:

1) Newly diagnosed biopsy proven prostate carcinoma who are referred to Diagnostic Imaging for MRI/MRSI

2) No previous radiation to prostate or pelvis

3) No hormonal treatment for prostate

4) The interval between the biopsy and MRSI: more than 6 weeks

5) Informed consent

Exclusion Criteria:

1) Contraindications for MRI (e.g. cardiac pacemaker)

2) Allergy to Latex

3) Contraindications for MRSI (e.g. history of abdomino-perineal resection of rectum)

4) Metals or any conditions (e.g. hip prosthesis) that can distort the local magnetic field

5) Previous prostate surgery for prostate carcinoma (including, TURP and cryosurgery), local or systemic treatment for prostate carcinoma (e.g. radiation, androgen deprivation), pelvic radiation (e.g. rectal cancer), rectal surgery, BCG for bladder cancer

6) Children (<18 years)

Links

Registration Number: NCT00429338
Study Information on Clinical Trials Registry (clinicaltrials.gov)