| Exclusion Criteria: | 1) Prior prostate cancer therapy (including radiation therapy to the prostate or pelvis, androgen ablation or antiandrogen systemic therapy)
2) The participant will need concurrent chemotherapy, radiotherapy, hormonal therapy or immunotherapy during the time of study
3) History of invasive cancer (excluding non-melanoma skin cancer) within the past two years. Participants who received curative treatment and have shown no evidence of recurrence for two years will be eligible.
4) Regular (more than once weekly) lycopene intake via supplementation and/or diet ( >/= 15 mg/d) within 30 days of the baseline visit. Participants will be excluded if they: ·have more than 2 servings of tomato sauce, juice, or soup per week OR ·have more than 4 servings of grape fruit, raw tomato, or watermelon per week OR ·have 1 serving of tomato sauce, juice or soup per week AND more than 2 servings of grape fruit, raw tomato, or watermelon per week
5) Finasteride (Proscar) or dutasteride (Avodart) treatment for the prior 6 months.
6) Alpha-sympathetic blocking agents (terazosin, doxazocin, tamsulosin) treatment for the prior 6 months
7) Participant has received any investigational medication within 30 days of the baseline visit or is scheduled to receive an investigational drug throughout the course of the study
8) History of allergic reactions attributed to compounds of similar chemical or biologic composition to lycopene eg. other carotenoids including lutein and beta-carotene; or a history of allergy to foods containing lycopene eg. tomatoes or tomato products, watermelon, guava, and pink grapefruit
9) Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. |