| Exclusion Criteria: | 1) Estimated Serum Creatinine Clearance <30 mL/min (according to Cock-Gault-formula)at the time gram positive bacteremia was diagnosed unless the patient is on dialysis.
2) Bilirubin >4x the upper limit of normal at the time gram positive bacteremia was diagnosed.
3) Treatment with an antibiotic, such as vancomycin, linezolid, tigercycline or daptomycin, effective against resistant gram positive bacterial infections, such as methicillin resistant staphylococci, for more than 48 hours within 72 hours of study medication initiation, unless treatment failed that is defined as a persistent fever, leukocytosis, and/or repeated positive blood cultures (CVC and peripheral) for 72 hours or longer of appropriate antibiotics treatment other than Daptomycin.
4) Documented gram positive bacteremia within last 1 month due to source other than CVC.
5) Patients who have participated in another investigational anti-infective study within 30 days.
6) History of hypersensitivity to lipopeptides.
7) Presence of additional source of infection with same organism cultured from blood, eg. endocarditis (as evidenced by vegetations on an echocardiogram), septic thrombosis.
8) Conditions with markedly decreased albumin in plasma (<1.5 g/dl), e.g., cirrhosis, nephritic syndrome, end-stage renal disease.
9) Prosthetic valve.
10) Oliguria defined as urine output of <20 cc/hour averaged over 24 hours.
11) Possible complicated CRBSI with persistent bacteremia for more than 48 hours on active antimicrobial therapy (such as osteomyelitis, endocarditits, and septic thrombosis).
12) Patients with diagnosis of pneumonia that is due to S. aureus organism, e.g, S .aureus from sputum or bronchial cultures.
13) CPK >10X max-normal in asymptomatic patients and CPK >5 max-normal in symptomatic patients. |