|Exclusion Criteria:||1) History of pancreatic cancer, previously diagnosed pancreatic mass or cyst, or previous pancreas surgery|
2) Any suspicion of pancreatic disease, based on clinical history (symptoms of possible pancreas problems: > 5 pound unintentional weight loss in the past 6 months, undiagnosed upper abdominal pain, loss of appetite, jaundice in the past 6 months, serum CA19-9 > 2 times the upper of normal (if checked within the past year by the patient's physician), physical examination (jaundice, cachexia), and/or imaging studies (pancreatic enlargement, mass or cyst, pancreatic duct dilation or stricture, pancreatic inflammation or atrophy)
3) Subjects will not be enrolled if they feel that they would not be interested in trreatment of pancreatic abnormalities found during this study, such as possible pancreas surgery
4) Medical illnesses that increase the risk of endoscopy and possible surgery: unstable angina, congestive heart failure requiring daily medication, chronic obstructive pulmonary disease (COPD or emphysema) requiring daily medication, pulmonary hypertension, obstructive sleep apnea requiring treatment with BIPAP or CPAP.
5) History of chronic kidney disease, serum creatinine > 1.8 mg/dl or estimated glomerulofiltration rate (eGFR) <30 ml/min, ongoing acute renal failure, cirrhosis of the liver, chronic hepatitis
6) History of moderate (generalized hives) or severe (facial swelling, airway reaction) reacation to intravenous radiographic contrast material. Subjects with a history of prior mild reaction to intravenous contrast (several hives) can be enrolled, but will be premedicated prior to CT scan with methylprednisolone 32 mg orally 12 hours and 2 hours prior to CT, as well as benadryl 50 mg orally one hour prior to CT.
7) Karnosfky performance status of < 60.
8) Partial or complete resection of their pancreas
9) History of obstruction in the upper GI tract such as esophageal or phyloric stricture, which causes difficulty swallowing or did not allow passage of an endoscope. Subjects who have been previously treated for a Schatzki's ring and currently have no difficulty swallowing may be enrolled.
10) Bleeding diathesis (clotting problems) or a history of thrombocytopenia (low platelet count)
11) Previous gastric or biliary surgery other than cholecystectomy
12) Cancer (other than basal cell of the skin) within last 5 years not in remission.
13) History of AIDS/HIV infection
14) Inability to provide informed consent
16) Morbid obesity with body weight > 350 pounds
17) History of metallic implants such as aneurysm clips, prosthetic joints, prosthetic valvves, pacemakers, defibrillators, or other contraindication to MRI