|1. To pretest the intervention and assessment procedures with five participants before starting the randomized pilot test.|
2. To evaluate the feasibility of a randomized controlled trial of a lifestyle intervention for chemotherapy-related heart failure in cancer survivors. The intervention will involve supervised cardiovascular exercise. Feasibility will be assessed by monitoring recruitment and retention rates, participant safety, intervention session attendance, contamination between study arms, and participant satisfaction.
3. To investigate the effect of the lifestyle intervention on primary outcomes (cardiorespiratory fitness, heart failure symptoms, heart failure disease progression), secondary outcomes (physical functioning, role functioning, health care utilization), adherence to behaviors (exercise), and behavioral mediators (exercise self-efficacy, and psychological distress). Because this is a pilot study, data will be used to develop effect size and variance estimates to be used in planning a larger randomized trial.
4. To explore Social Cognitive Theory predictors of adherence to exercise recommendations. We will test psychometric characteristics of the measures of these variables, and explore associations consistent with the conceptual model (Figures 1 and 2).
5. To evaluate the feasibility and safety of a home-based exercise intervention for cancer survivors with chemotherapy-related heart failure who are unable to participate in the randomized trial of the supervised intervention.