| Exclusion Criteria: | 1) Known history of hypersensitivity to gentamicin or bovine collagen
2) Undergoing emergency surgery (urgent surgery is allowed if informed consent is obtained and the study procedures can be performed). Emergency surgery includes cases where standard bowel preparation and other preoperative assessments cannot be done.
3) Undergoing a significant concomitant surgical procedure (e.g., hysterectomy). The following concomitant procedures are allowed: appendectomy, cholecystectomy, oophorectomy, liver biopsy/wedge resection (not liver resection).
4) Undergoing a laparoscopic, laparoscopic-assisted, or other minimally invasive surgical approach involving a laparotomy incision less than 7 cm. For example, hand assisted left colectomy is allowed as long as a 7 cm or greater laparotomy incision is used.
5) History of prior laparotomy within the last 60 days of this planned procedure.
6) Planned to undergo a second laparotomy or colorectal surgical procedure (e.g. colostomy or ileostomy takedown) within 60 days of this planned first procedure.
7) Evidence preoperatively of any of the following: sepsis, sever sepsis, or septic shock (note that systemic inflamatory response syndrome (SIRS) alone is not an exclusion criterium).
8) Current abdominal wall infection/surgical site infection from previous laparotomy/laparoscopy or for any reason.
9) Receiving antibiotic therapy within the 1 week prior to the date of surgery.
10) Preoperative evaluation suggests intra-abdominal process that might preclude full closure of the skin
11) History of ongoing treatment (e.g. chemotherapy, radiation) for non-colorectal cancer.
12) Recent history of significant drug or alcohol abuse
13) Preoperative prothrombin time (PT) greater than 1.5 times upper limit of normal
14) Pregnant, lactating, or of childbearing potential not practicing a birth control method with a high degree of reliability.
15) Postsurgical life expectancy less than or equal to 60 days, in the investigator's or sponsor's opinion.
16) Refusal to accept medically indicated blood products.
17) Previous participation in this or any other active Innocoll Gentamicin-Collagen Sponge study.
18) Participation within 30 days before the start of this study in any experimental drug or device study, or currently participating in a study in which the administration of investigational drug or devise within 60 days is anticipated.
19) Surgeon does not believe that it will be possible to insert 2 sponges above the fascia in the patient (e,g, in a very thin patient planned to have a small incision).
20) Patients with anterior abdominal wall mesh that is not planned to be completely removed during the planned procedure
21) Presence of prosthetic cardiac valve |