CLINICAL TRIAL SUMMARY

MDACC Study No:2009-0239 (clinicaltrials.gov NCT No: NCT00920140)
Title:An Open-Label, Dose-Escalation, Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib (GSK1120212) in Subjects with Relapsed or Refractory Leukemias
Principal Investigator:Gautam Borthakur
Treatment Agent:GSK1120212
Study Status:Terminated
Study Description:The goal of Phase 2 of this clinical research study is to learn if Trametinib
(GSK1120212) can help to control leukemia. The safety of this drug will also
be studied.

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Disease Group:Leukemia
Phase of Study:Phase I/Phase II
Treatment Agents:GSK1120212
Treatment Location:Both at MDACC & outside MDACC at one or more Collaborating Sites or Institutions
Estimated Length of Stay in Houston:N/A
Supported By:GlaxoSmithKline
Return Visit:Every 4 weeks while on study.
Home Care:N/A


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Physician Name:Gautam Borthakur
Dept:Leukemia
For Clinical Trial Enrollment:713-563-1586
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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