CLINICAL TRIAL SUMMARY

MDACC Study No:2010-0696 (clinicaltrials.gov NCT No: NCT01199367)
Title:A phase I/II study to evaluate the safety, tolerability, and preliminary efficacy of KW-2450 in combination with lapatinib and letrozole in subjects with advanced or metastatic breast cancer whose tumor overexpress HER2
Principal Investigator:Naoto Ueno
Treatment Agent:KW-2450; Lapatinib; Letrozole
Study Status:Terminated
Study Description:The goal of Phase 1 of this clinical research study is to find the highest
tolerable dose of KW-2450 when given in combination with lapatinib and
letrozole to patients with advanced breast cancer. The safety of this drug
combination will also be studied.

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Disease Group:Breast
Phase of Study:Phase I/Phase II
Treatment Agents:KW-2450
Lapatinib
Letrozole
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Kyowa Hakko Kirin Pharma, Inc
Return Visit:
Home Care:


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Physician Name:Naoto Ueno
Dept:Breast Medical Oncology
For Clinical Trial Enrollment:713-792-2817
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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