CLINICAL TRIAL SUMMARY

MDACC Study No:2011-0030 (clinicaltrials.gov NCT No: NCT01424982)
Title:PHASE II STUDY OF COMBINATION OF HYPER-CVAD AND PONATINIB IN PATIENTS WITH PHILADELPHIA (PH) CHROMOSOME POSITIVE AND/OR BCR-ABL POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
Principal Investigator:Susan O'Brien
Treatment Agent:Adriamycin; Citrovorum; Cyclophosphamide; Cytarabine; Dexamethasone; G-CSF; Methotrexate; MESNA; Ponatinib; Prednisone; Solumedrol; Vincristine
Study Status:Closed
Study Description:The goal of this clinical research study is to learn if intensive chemotherapy
combined with ponatinib, followed by maintenance therapy, can help to control
ALL with the Ph chromosome and/or BCR-ABL. The safety of this treatment will
also be studied.

Ponatinib may cause a blood clot to form in an artery or in a vein. Depending
on the location of the clot, this could cause a heart attack, a stroke, severe
damage to other tissue, or death. A blood clot may occur within 2 weeks after
you start taking the drug. About 25% (1 in 4) of patients taking the drug form
an abnormal clot. Blood clots can occur in patients that do not have other
known risk factors for forming clots. If you develop a blood clot, you will
need to stop taking ponatinib. In some cases, emergency surgery could be needed
to remove the clot and restore blood flow.

Hide details for General InformationGeneral Information

Disease Group:Leukemia
Phase of Study:Phase II
Treatment Agents:Adriamycin
Citrovorum
Cyclophosphamide
Cytarabine
Dexamethasone
G-CSF
Methotrexate
MESNA
Ponatinib
Prednisone
Solumedrol
Vincristine
Treatment Location:Only at MDACC
Estimated Length of Stay in Houston:
Supported By:Ariad
Return Visit:
Home Care:


Hide details for Study Contact InformationStudy Contact Information

Physician Name:Susan O'Brien
Dept:Leukemia
For Clinical Trial Enrollment:713-792-7543
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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