CLINICAL TRIAL SUMMARY

MDACC Study No:2011-0142LEUKEMIA (clinicaltrials.gov NCT No: NCT01109069)
Title:A Long-Term Safety Study of Bruton’s Tyrosine Kinase (Btk) Inhibitor PCI-32765 in B cell Lymphoma and
Chronic Lymphocytic Leukemia
Principal Investigator:Susan O'Brien
Treatment Agent:PCI-32765
Study Status:Closed
Study Description:The goal of this study is to learn if PCI-32765 (also called Ibrutinib) given 1
time a day is tolerable by looking at the side effects for patients that have
taken PCI-32765 in a previous study. Researchers also want to learn if
PCI-32765 can help to control the disease.

PCI-32765 is a type of drug called a kinase inhibitor. Kinases are proteins
inside cells that help cells live and grow. The specific kinase blocked by
the study drug is believed to help blood cancer cells live and grow. By
blocking the activity of this specific kinase, it is possible that the study
drug may kill the cancer cells or stop them from growing.

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Disease Group:Leukemia
Phase of Study:N/A
Treatment Agents:PCI-32765
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Pharmacyclics, Inc.
Return Visit:
Home Care:


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Physician Name:Susan O'Brien
Dept:Leukemia
For Clinical Trial Enrollment:713-792-7543
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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