CLINICAL TRIAL SUMMARY

MDACC Study No:2011-0527 (clinicaltrials.gov NCT No: NCT01606579)
Title:An Open-Label, Dose-Escalation Phase I/II Study of PRI-724 for Patients with Advanced Myeloid Malignancies
Principal Investigator:Jorge Cortes
Treatment Agent:PRI-724
Study Status:Open
Study Description:The goal of Part I of this clinical research study is to learn the highest
tolerable dose of PRI-724 that can be given to patients with acute advanced
myeloid cancer. Acute means one of the following disease types: advanced acute
myeloid leukemia, myelodysplastic syndrome, or accelerated phase chronic
myeloid leukemia. Together, participants with these diseases make up the Acute
Group.

The goal of Part II of this clinical research study is to learn the highest
tolerable dose of PRI-724 that can be given to patients with chronic myeloid
leukemia . These participants make up the Non-Acute Group.”

In Part III, researchers will study the safety of PRI-724 combined with a
standard drug, dasatinib or cytarabine. Part III includes participants in both
the Acute and Non-Acute Groups. Researchers also want to learn if PRI-724
combined with dasatinib can help to control CML, and if PRI-724 combined with
cytarabine can help control AML in patients age 65 years or older.

PRI-724 is designed to keep cancer cells from sending and receiving signals
that they need to grow and spread.

Hide details for General InformationGeneral Information

Disease Group:Leukemia
Phase of Study:Phase I/Phase II
Treatment Agents:PRI-724
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:PRISM BioLab Corporation
Return Visit:
Home Care:


Hide details for Study Contact InformationStudy Contact Information

Physician Name:Jorge Cortes
Dept:Leukemia
For Clinical Trial Enrollment:713-794-5783
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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