CLINICAL TRIAL SUMMARY

MDACC Study No:2011-0805 (clinicaltrials.gov NCT No: NCT01476787)
Title:A PHASE 3 OPEN-LABEL RANDOMIZED STUDY TO COMPARE THE EFFICACY AND SAFETY OF RITUXIMAB PLUS LENALIDOMIDE (CC-5013) VERSUS RITUXIMAB PLUS CHEMOTHERAPY FOLLOWED BY RITUXIMAB IN SUBJECTS WITH PREVIOUSLY UNTREATED FOLLICULAR LYMPHOMA
Principal Investigator:Nathan Fowler
Treatment Agent:Lenalidomide; Rituximab
Study Status:Open
Study Description:The goal of this clinical research study is to learn if Revlimid®
(lenalidomide) when given with rituximab can help to control FL and also
increase the length of the disease response. This will be compared with the
current standard of care, which is rituximab plus chemotherapy.

Lenalidomide is designed to change the body's immune system. It may also
interfere with the development of tiny blood vessels that help support tumor
growth. This may decrease the growth of cancer cells. FL blocks the immune
system's ability to attack and kill tumor cells. Lenalidomide has been shown
to restore the immune cells’ ability to attack and kill tumor cells.
Researchers want to find out if adding lenalidomide can restore the immune
system's defenses against tumor cells, while treating the disease at the same
time.

Rituximab is designed to attach to cancer cells and damage them, which may
cause the cancer cells to die. It is also designed to cause the immune system
to attack cancer cells.

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Disease Group:Lymphoma
Phase of Study:Phase III
Treatment Agents:Lenalidomide
Rituximab
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Celgene Corporation
Return Visit:
Home Care:


Hide details for Study Contact InformationStudy Contact Information

Physician Name:Nathan Fowler
Dept:Lymphoma/Myeloma
For Clinical Trial Enrollment:713-792-2860
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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