CLINICAL TRIAL SUMMARY

MDACC Study No:2012-0054 (clinicaltrials.gov NCT No: NCT01565668)
Title:A Phase 2, Randomized, Open-Label Study of the Safety and Efficacy of Two Doses of Quizartinib (AC220; ASP2689) in Subjects with FLT3-ITD Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
Principal Investigator:Jorge Cortes
Treatment Agent:AC220
Study Status:Closed
Study Description:The goal of this clinical research study is to compare the safety and
effectiveness of 2 doses of quizartinib in people with relapsed or refractory
AML.

The study drug is designed to block the FLT3 receptor on leukemia cells to stop
the chemical reaction that happens when FLT3 is activated. This may slow or
stop cancer cell division, and may lead to cancer cell death. Quizartinib may
also work against other receptors that are involved in leukemia cell division
and growth.

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Disease Group:Leukemia
Phase of Study:Phase II
Treatment Agents:AC220
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Ambit Biosciences Corporation
Leukemia SPORE
Return Visit:
Home Care:


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Physician Name:Jorge Cortes
Dept:Leukemia
For Clinical Trial Enrollment:713-794-5783
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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