CLINICAL TRIAL SUMMARY

MDACC Study No:2012-0669 (clinicaltrials.gov NCT No: NCT01746836)
Title:Ponatinib as Second Line Therapy for Patients with Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib, Dasatinib or Nilotinib
Principal Investigator:Jorge Cortes
Treatment Agent:Ponatinib
Study Status:Closed
Study Description:The goal of this clinical research study is to learn if ponatinib can help to
control CML in chronic phase. The safety of this drug will also be studied.

Ponatinib is designed to block the function of BCR-ABL, which is the abnormal
protein responsible for causing CML. This may cause the cancer cells to die.

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Disease Group:Leukemia
Phase of Study:Phase II
Treatment Agents:Ponatinib
Treatment Location:Only at MDACC
Estimated Length of Stay in Houston:
Supported By:Ariad Pharmaceuticals
Return Visit:
Home Care:


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Physician Name:Jorge Cortes
Dept:Leukemia
For Clinical Trial Enrollment:713-794-5783
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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