CLINICAL TRIAL SUMMARY

MDACC Study No:2012-0681 (clinicaltrials.gov NCT No: NCT01623349)
Title:Phase I study of the oral PI3kinase inhibitor BKM120 or BYL719 and the oral PARP inhibitor olaparib in patients with recurrent triple negative breast cancer or high grade serous ovarian cancer
Principal Investigator:Shannon Westin
Treatment Agent:AZD2281; BKM120; BYL719
Study Status:Open
Study Description:The goal of this Phase 1 clinical research study is to learn the highest
tolerable dose of the combination of the drugs BKM120 and olaparib or BYL719
and olaparib that can be given to patients with recurrent breast or ovarian
cancer. The safety of these drugs will also be studied.

BKM120, BYL719, and olaparib are both designed to block the growth and division
of cancer cells, which may cause the cells to die.

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Disease Group:Breast; Ovary
Phase of Study:Phase I
Treatment Agents:AZD2281
BKM120
BYL719
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Dana Farber Cancer Institute
Return Visit:
Home Care:


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Physician Name:Shannon Westin
Dept:Gynecologic Oncology
For Clinical Trial Enrollment:713-794-4314
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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