|The goal of Phase I of this clinical research study is find the highest |
tolerable dose of clofarabine that can be given with decitabine, idarubicin,
and cytarabine to patients with acute leukemia.
The goal of Phase II of this study is to learn if decitabine followed by the
combination of clofarabine, idarubicin, and cytarabine can help to control
acute leukemia. The safety of this drug combination will also be studied.
Decitabine and idarubicin are designed to damage the DNA (the genetic material
of cells). This may cause cancer cells to die.
Clofarabine is designed to interfere with the growth and development of cancer
Cytarabine is designed to insert itself into DNA and stop the DNA from