| Inclusion Criteria: | 1) Patient must be > or = 18 years of age with ECOG PS of < or = 3.
2) Have tissue diagnosis of a clinically resectable T1 or T2 , N0 or non-hilar N1, M0 NSCLC (squamous carcinoma, large cell carcinoma, or adenocarcinoma including bronchoalveolar carcinoma) established prior to randomization.
3) A patient without a preoperative tissue diagnosis, but with clinically suspected NSCLC that fits the above criteria is eligible provided the tissue diagnosis is confirmed intraoperatively.
4) Must have CT scan of the chest and upper abdomen to include the liver and adrenal glands within 60 days of the date of the pulmonary resection.
5) Patient that has not had a mediastinoscopy should have no mediastinal adenopathy on CT of the chest defined as no lymph node > 1 cm in the shortest axis.
6) Patient is a candidate for a complete resection of the carcinoma via pneumonectomy, lobectomy, bilobectomy, or anatomic segmentectomy with or without sleeve resection, as noted in the surgical plan.
7) Patient or patient's legally acceptable representative must provide a signed and dated informed consent prior to registration and study related procedures.
8) If patient is a survivor of a prior cancer, the following must be met: a) patient has undergone potentially curative therapy for all prior malignancies, b) no evidence of prior malignancy for at least 5 years except for effectively treated basal or squamous cell carcinoma of the skin, carcinoma in-situ of the cervix or carcinoma in-situ of the breast treated by surgery alone and c) patient is deemed by their treating physician to be at low risk for recurrence from prior malignancies.
9) Patient with right-sided lesions must have at least # 2R, 4R, 7 and 10R examined intraoperatively. If the nodes are found, they must be sampled and proven negative by frozen section.
10) Patient with left-sided lesions must have at least nodal stations # 5, 6, 7, and 10L examined intra-operatively. If the nodes are found, they must be sampled and proven negative by frozen section. |