CLINICAL TRIAL SUMMARY

MDACC Study No:BTTC11-02 (clinicaltrials.gov NCT No: NCT01266031)
Title:Phase I/II Adaptive Randomized Trial of Bevacizumab versus Bevacizumab plus Vorinostat in Adults with Recurrent Glioblastoma
Principal Investigator:Marta Penas-Prado
Treatment Agent:Avastin; Vorinostat
Study Status:Open
Study Description:The goal of this Phase I portion of this clinical research study is to find the
highest tolerable dose of bevacizumab with or without vorinostat, that can be
given to patients with malignant gliomas. The safety of these drug combinations
will also be studied.

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Disease Group:Brain; CNS
Phase of Study:Phase I/Phase II
Treatment Agents:Avastin
Vorinostat
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:BRAIN TUMOR TRIALS COLLABORATIVE (BTTC)
Genentech, Inc.
Merck Sharp and Dohme Corp.
Return Visit:
Home Care:


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Physician Name:Marta Penas-Prado
Dept:Neuro Oncology
For Clinical Trial Enrollment:713-792-2883
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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