|Inclusion Criteria:||1) Participants must be 18 years of age or older.|
2) Histologically documented malignant melanoma of the conjunctiva/eyelid greater than or equal to 1 millimeter in thickness, or those less than 1 mm thick that have evidence of ulceration, mitotic figures or are Clark IV.
3) A CXR, liver enzymes, and a head and neck comptuted tomography (CT) or magnetic resonance imaging (MRI) negative for evidence of metastasis.
4) Participant must have a negative ultrasound of regional lymph nodes (i.e., within 6 weeks of study enrollment).
5) Patient provided written informed consent. In the event that non-English speaking participants are eligible for this study, a short form (if applicable) or an ICD in their language, will be utilized and completed in accordance with the MDACC Policy for Consenting Non-English Speaking Participants.