MDACC Study Summary ID02-139

Study Summary
No. ID02-139:.......Pancreas......Melissa Bondy......Epidemiology

Study Summary Title



Study Summary Number:	ID02-139

Study Title:	Pancreas Cancer Family Study

Physician

New Patient Referral



Name:	Melissa Bondy	Patients Call:	800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)

Dept:	Epidemiology	Referring MD Call:	800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)

Phone:	713-794-5264 Contact us about clinical trials

General Information



Disease Group:	Pancreas	Supported By:	N/A

Phase of Study:	N/A	Return Visit:	N/A

Treatment Agents:	None	Home Care:	N/A

Treatment Loc:	Independent Multicenter Arrangements

Estimated Length of Stay in Houston:	N/A


Description/ Intervention:	The goal of this research study is to investigate the role of genes that may point to a higher risk of developing pancreatic cancer.

Study Objectives / Outcomes

Our study is part of a multicenter, multidisciplinary Pancreatic Cancer Genetic Epidemiology (PACGENE) consortium to identify susceptibility genes in high risk FPC pedigrees using cutting-edge genetic analysis methods.
1. To identify high risk pedigrees for genetic linkage analysis utilizing established pancreatic cancer family research resources. We will recruit and screen new pancreatic cancer patients over 5 years to accrue biospecimens, tumor tissues, and risk factor data (including family history) from available relevant family members of familial pancreatic cancer (FPC) pedigrees suitable for genetic linkage studies (those with 3 or more persons affected with pancreatic cancer and those providing expected lod score of 0.3 or higher.
2. To genotype informative individuals in high-risk FPC pedigrees with 400 evenly spaced markers (~ 10 centimorgan intervals) throughout the genome. We will also perform genotyping with genome-wide microsatellite markers.
3. To map a pancreatic cancer susceptibility gene(s) by genetic linkage analysis of the high-risk FPC pedigrees. We propose to use conventional parametric linkage strategies, but will also implement the latest methods that incorporate environmental covariates in the analysis.

Study Status Information



Study Activation / Registration Date:	06/19/2002

IRB Review and Approval Date:	05/15/2002

Study Type:	Therapeutic

Recruitment Status:	Open

Projected Accrual:	4770

Enrollment Eligibility

If you do not meet the enrollment eligibility, there may be other treatment options for you. Please Contact the Referral Office for more information.

Inclusion Criteria:

1) An effected or uneffected member of a family, age 18 or older, that has two or more reported pancreatic cancers in the family.

Exclusion Criteria:

1) Cases under age 18.

2) Relatives of pancreatic cancer cases under age 18.

Links

Registration Number: NCT00526578
Study Information on Clinical Trials Registry (clinicaltrials.gov)