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Study Summary
No. IDP00-075:.......Gynecology......Anuja Jhingran......Radiation Oncology
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Study Summary Title
Study Summary
Number:		IDP00-075
Study Title:A pilot study of early changes in DNA array expression following chemo-radiation treatment of cervical cancer
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Physician New Patient Referral
Name:Anuja JhingranPatients Call:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)
Dept:Radiation OncologyReferring MD
Call:		800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)
Phone:713-792-3400
Contact us about clinical trials
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General Information
Disease Group:GynecologySupported By:N/A
Phase of Study:N/AReturn
Visit:		Not applicable
Treatment
Agents:		NoneHome Care:Not applicable
Treatment Loc:Only at MDACC
Estimated
Length of Stay
in Houston:		Not applicable
Description/
Intervention:		The goal of this clinical research study is to find out if the expression of
certain genes is linked with the response of cervical cancer to radiation.
Researchers will study a large number of genes located in tumor material to
learn this information.
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Study Objectives / Outcomes
1. To obtain preliminary descriptive data on early changes in tumor DNA array expression following chemo-radiation of cervical cancer. These data will permit the design a future studies to correlate array expression changes with clinical outcome.

2. To quantify the degree of therapy-induced apoptosis following chemo-radiation of cervical cancer in order to design future studies to correlate apoptosis levels with clinical outcome.

3. To store material to later correlate the tumor DNA array expression with specific strains of tumor-related human papilloma virus (HPV)
    4. To correlate changes in biomarker expression with clinical outcome and findings of the DNA array analyses.
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    Study Status Information
    Study Activation / Registration Date:06/20/2000
    IRB Review and Approval Date:03/16/2000
    Study Type:Therapeutic
    Recruitment Status:Closed
    Projected Accrual:N/A
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    Enrollment Eligibility
    If you do not meet the enrollment eligibility, there may be other treatment options for you. Please Contact the Referral Office for more information.
    Inclusion Criteria:1) 1. Newly diagnosed cervical cancer: clinical Stage IB -IIIB 2. Invasive pure squamous cell carcinoma 3. Planned treatment with concurrent cisplatinum/5-flourouracil chemotherapy and pelvic radiation
    Exclusion Criteria:1) 1. Previous cervical cancer treatment including but not limited to transvaginal cone irradiation
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    Links
    Registration Number: NCT00512551
    Study Information on Clinical Trials Registry (clinicaltrials.gov)
    Other Links:
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    Results

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