CLINICAL TRIAL SUMMARY

MDACC Study No:RTOG0929 (clinicaltrials.gov NCT No: NCT01026493)
Title:A Randomized Phase I/II Study of ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma
Principal Investigator:John DeGroot
Treatment Agent:ABT-888; Temozolomide
Study Status:Closed
Study Description:The goal of Phase I of this clinical research study is to find the highest
tolerable dose of the combination of ABT-888 and temozolomide that can be given
to patients with glioblastoma.

The goal of Phase II of this clinical research study is to learn if the
combination of temozolomide and ABT-888 can help to control glioblastoma. Two
(2) different dose schedules of the study drug combination will also be
compared.

The safety of these drug combinations will also be studied in both phases.

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Disease Group:Brain; CNS
Phase of Study:Phase I/Phase II
Treatment Agents:ABT-888
Temozolomide
Treatment Location:Both at MDACC & and Other Sites
Estimated Length of Stay in Houston:
Supported By:Radiation Therapy Oncology Group (RTOG)
Return Visit:
Home Care:


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Physician Name:John DeGroot
Dept:Neuro Oncology
For Clinical Trial Enrollment:713-792-2883
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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