Goal 1: To determine sensitivity and specificity of microsatellite analysis (MSA) of urine sediment, using a panel of 14 microsatellite markers, in detecting bladder cancer in participants requiring cystoscopy. This technique will be compared to the diagnostic standard of cystoscopy, as well as to urine cytology.
Goal 2: To determine the temporal performance characteristics of microsatellite analysis of urine sediment.
Goal 3: To determine which of the 14 individual markers or combination of markers that make up the MSA test are most predictive of the presence of bladder cancer.
Aim 1: This study will test the specificity of MSA in two groups of participants without bladder cancer─both healthy, normal controls─as well as participants without bladder cancer who have conditions known to confound the performance of previous urinary tests for bladder cancer.
Aim 2: This study will test the sensitivity of MSA in the presence of clinically evident, pathologically confirmed bladder cancer.
Aim 3: This study will test the sensitivity and specificity of MSA for the detection of bladder cancer among participants undergoing surveillance for bladder cancer.
Aim 4: This study will test the value of MSA to predict subsequent development of bladder cancer among participants with a history of bladder cancer.