CLINICAL TRIAL SUMMARY

MDACC Study No:2006-0638 (clinicaltrials.gov NCT No: NCT00543504)
Title:A PHASE 1 STUDY OF BEVACIZUMAB IN COMBINATION WITH 1) SUNITINIB, 2) SORAFENIB, 3) ERLOTINIB AND CETUXIMAB, 4) TRASTUZUMAB AND LAPATINIB
Principal Investigator:Funda Meric-Bernstam
Treatment Agent:Bevacizumab; Cetuximab; Erlotinib; Lapatinib; Sorafenib; Sunitinib Malate; Trastuzumab
Study Status:Closed
Study Description:The goal of this clinical research study is to find the highest tolerable dose
of
Avastin™ that can be given in combination with 4 other study drug/drug
combinations. It will be given with sunitinib, with sorafenib, with a
combination of erlotinib and cetuximab, and with a combination of trastuzumab
and lapatinib. The safety and effectiveness of these drug combinations will
also be studied.

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Disease Group:Advanced Cancers
Phase of Study:Phase I
Treatment Agents:Bevacizumab
Cetuximab
Erlotinib
Lapatinib
Sorafenib
Sunitinib Malate
Trastuzumab
Treatment Location:Independent Multicenter Arrangements
Estimated Length of Stay in Houston:N/A
Supported By:N/A
Return Visit:Patients are seen and evaluated in the phase I clinic weekly during cycle 1,
and at the end of each cycle thereafter. Other visits include the IV
treatments specified by the study and optional research correlative studies
(blood draws, DCE-MRI).
Home Care:Patient will be given oral medication (sorafenib, sunitinib, erlotinib,
lapatinib) per treatment protocol to take at home.


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Physician Name:Funda Meric-Bernstam
Dept:Investigational Cancer Therapeutics
For Clinical Trial Enrollment:713-563-1930
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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