|Study Description:||The overall goal of this study was to compare the effects, good and/or bad, of |
adding the chemotherapy drugs carboplatin and/or isotretinoin to the standard
treatment combination of chemotherapy and radiation, in treating patients with
high-risk medulloblastoma. Researchers want to find out if adding one or both
chemotherapy drugs is more effective in treating the disease than giving
standard therapy alone. As of January 27, 2015, enrollment was suspended when
the results showed that isotretinoin was not better than standard therapy with
or without carboplatin. As a result, patients who enroll on this study will no
longer receive isotretinoin.
The main aim of this study is:
To find out if giving the drug carboplatin along with radiation therapy is more
effective than giving radiation therapy alone.
This study is called a clinical trial. A clinical trial is a research study
involving treatment of a disease in human patients. This study is organized by
Children’s Oncology Group (COG). COG is an international research group that
conducts clinical trials for children with cancer. More than 200 hospitals in
North America, Australia, New Zealand, and Europe are members of COG.