|Study Description:||The overall goal of this study is to compare the effects, good and/or bad, of |
adding the chemotherapy drugs carboplatin and/or isotretinoin to the standard
treatment combination of chemotherapy and radiation, in treating patients with
high-risk medulloblastoma. Researchers want to find out if adding one or both
chemotherapy drugs is more effective in treating the disease than giving
standard therapy alone.
The main aims of this study are:
To find out if giving the drug carboplatin along with radiation therapy is more
effective than giving radiation therapy alone.
To find out if the drug isotretinoin can improve the survival of subjects with
This study is called a clinical trial. A clinical trial is a research study
involving treatment of a disease in human patients. This study is organized by
Children’s Oncology Group (COG). COG is an international research group that
conducts clinical trials for children with cancer. More than 200 hospitals in
North America, Australia, New Zealand, and Europe are members of COG.