| Exclusion Criteria: | 1) Participants with active gastric or duodenal ulcers or a history of ulcers requiring prophylactic H2 blockers.
2) Participants with active pulmonary infections or recent history of pulmonary infection (within 1 month).
3) Participants receiving inhaled steroid therapy on a regular basis.
4) Participants with acute intercurrent illness, or participants who had surgery within the preceding 4 weeks unless they have fully recovered.
5) Participants requiring chronic ongoing treatment with NSAIDs.
6) Participants who are allergic to aspirin or sulfanamides.
7) Participants with history of stroke, transient ischemic attack, uncontrolled hypertension, and/or angina pectoris.
8) Participants who are pregnant and/or breast-feeding.
9) Participants (men or women) of childbearing potential who are not using an effective method of contraception.
10) History of cardiovascular diseases that might include one of the following: myocardial infarction, angina, coronary angioplasty, congestive heart failure, stroke, or coronary bypass surgery.
11) Diagnosis of diabetes
12) History of deep venous thrombosis, pulmonary embolism, systemic lupus erythermatous, family history of protein S or C deficiencies, prior heparin-induced thrombocytopenia, or known Factor V Leiden mutation.
13) Family history of premature CAD. This is defined as individuals with either: 1) father with MI prior to age 55, or 2) mother with MI prior to age 60. |