CLINICAL TRIAL SUMMARY

MDACC Study No:NABTC07-01 (clinicaltrials.gov NCT No: NCT00650923)
Title:Phase I Trial of Aflibercept (VEGF Trap) with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients with Malignant Glioma
Principal Investigator:John DeGroot
Treatment Agent:Temozolomide; VEGF-Trap
Study Status:Closed
Study Description:The goal of this clinical research study is to find the highest tolerable dose
of VEGF Trap that can be given in combination with temozolomide during and
after radiation therapy. The safety of this combination will also be studied.

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Disease Group:Brain; CNS
Phase of Study:Phase I
Treatment Agents:Temozolomide
VEGF-Trap
Treatment Location:Both at MDACC & outside MDACC at one or more Collaborating Sites or Institutions
Estimated Length of Stay in Houston:N/A
Supported By:NCI/ABTC
Return Visit:Every 2 weeks
Home Care:Patients will take temozolomide at home.


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Physician Name:John DeGroot
Dept:Neuro Oncology
For Clinical Trial Enrollment:713-792-2883
For General Questions about Clinical Trials:800-392-1611 (in U.S.A.) 713-792-6161 (outside U.S.A.)


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