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Sanjay S. Shete, MSc, PhD

Research Interests:
Statistics, epidemiology, genomic imprinting, gene-gene interactions

The determinants of many traits of humans include genetic components, although in most cases, their locations on the chromosomes are not known. My research focuses on the development and implementation of statistical methods for analyzing family and pedigree data to identify genes that cause disease. One of my current areas of research is to develop methods for gene-gene and gene-environmental interaction and apply them to cancer data. Statistical methods applied to genetic and molecular data play a key role in uncovering the often complex relationship between important traits of living organisms and their genetic bases.

I have developed methods for testing linkage and genomic imprinting in extended pedigrees. Currently, I am developing methods for testing gene-gene and gene-environment interactions in a case-only study design.

Selected Publications
Shete S, Zhou X. Parametric approach to genomic imprinting analysis with applications to Angelman's syndrome. Hum Hered 59:26-33, 2005

Xu H, Spitz MR, Amos CI, Shete S. Complex segregation analysis reveals a multigene model for lung cancer. Hum Genet 116:121-127, 2005

Xu H, Wu X, Spitz MR, Shete S. Comparison of haplotype inference methods using genotypic data from unrelated individuals. Hum Hered 58:63-68, 2004

Shete S, Zhou X, Amos CI. Genomic imprinting and linkage test for quantitative trait loci in extended pedigrees. Am J Hum Genet 73:933-938, 2003

Shete S, Jacobs KB, Elston RC. Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: Weighting sums and differences. Hum Hered 55:79-85, 2003

Additional Information:

Department: Epidemiology

Department URL:

Division/Section: Cancer Prevention and Population Sciences

Last Updated: 06/30/2006